Clinical characteristics and removal approaches of tracheal and bronchial foreign bodies in elders

The symptoms of tracheobronchial foreign body in the elderly are not typical, so they are often missed or misdiagnosed. This study aims to depict the clinical characteristics of tracheobronchial foreign body inhalation in the elderly. We retrospectively analysed the clinical data of elder patients (age ≥ 65 years) diagnosed with tracheal and bronchial foreign bodies. The data included age, sex, clinical symptoms, type and location of foreign bodies, prehospital duration, Chest CT, bronchoscopic findings, and frequencies and tools for removing these elderly patients' tracheal and bronchial foreign bodies. All patients were followed up for a half year. Fifty-nine cases were included, of which only 32.2% had a definite aspiration history. Disease duration > 30 days accounted for 27.1% of the patients. 27.1% of the patients had a history of stroke, and 23.8% had Alzheimer's Disease. Regarding clinical symptoms, patients mainly experience cough and expectoration. The most common CT findings were abnormal density shadow (37.3%) and pulmonary infiltration (22.0%). Under bronchoscopy, purulent secretions were observed in 52.5% of patients, and granulation tissue hyperplasia was observed in 45.8%. Food (55.9%) was the most common foreign object, including seafood shells (5.1%), bones (20.3%), dentures (18.6%), and tablets (20.3%). The success rate of foreign body removal under a bronchoscope was 96.7%, 28.8% of the foreign bodies were on the left and 69.5% on the right. 5.1% of the elderly patients required rigid bronchoscopy, and 6.8% required two bronchoscopies. In elderly cohorts, tracheal foreign bodies are obscured by nonspecific clinical presentations and a paucity of aspiration history, challenging timely diagnosis. Predominantly constituted by food particles, with a notable predilection for the left bronchial tree, these cases demand skilled bronchoscopic management, occasionally requiring sophisticated approaches for successful extraction.


General characteristics of elders with tracheal and bronchial foreign bodies
In total, 59 elderly patients diagnosed with tracheal and bronchial foreign bodies and treated by bronchoscopy were enrolled in our study.The ratio of males (39) to females (20) was 1.95:1, underscoring a male predominance and a higher incidence in the elderly.The age distribution ranged from 65 to 86 years, with a median age of 72 (IQR 67-80) years; elders aged 65 to 75 years accounted for 61.0%(36/59), and those older than 75 years accounted for 39.0% (23/59) of patients.The analysis reveals a broad duration spectrum for foreign body presence, ranging from less than a day to over a year, with a median of one week.A notable fraction of the cohort had a recorded history of aspiration.The examination of comorbidities illustrated a significant prevalence of hypertension alongside other conditions such as stroke and Alzheimer's disease.Symptomatically, cough and sputum were prevalent, with most patients being administered antibiotics, primarily β-lactam types, reflecting a common therapeutic approach.The duration of antibiotic use varied, with a significant portion extending to a week, highlighting the clinical management practices in these cases (Table 1).There were 34 (57.6%)patients from urban areas and the remaining 25 (42.4%) from rural areas (Table 1).Overall, urban patients took less time to see a doctor after developing symptoms than rural patients (Fig. 1).

Chest CT and bronchoscopic findings of tracheal and bronchial foreign bodies
Chest CT scans in patients with tracheal and bronchial foreign bodies revealed diverse findings: 15.3% normal scans, 22% pulmonary infiltration, 11.9% atelectasis, 10.2% radio-opaque bodies, 37.3% abnormal density shadows, and 3.4% space-occupying lesions.Bronchoscopic examinations frequently showed granulation tissue hyperplasia, erosions, and purulent secretions, reflecting the complexity of these cases.These results highlight the varied presentations of airway foreign bodies, emphasizing the need for thorough diagnostic strategies.(Table 2).

Types and location of tracheal and bronchial foreign bodies
The study reveals a variety of tracheal and bronchial foreign bodies, notably pills and dentures.Food particles, particularly prune kernels (13.6%) and chicken bones (8.5%), were significant, highlighting dietary risks (Fig. 2).A majority of foreign bodies were located in the right middle bronchus (35.6%) and right lower lobar bronchus (22.0%), suggesting anatomical susceptibilities.Bronchoscopic detection was highest in the right bronchus (69.5%), followed by the left bronchus (28.8%) and trachea (1.7%).These findings suggest trends in airway foreign body incidents, informing clinical preventive and management approaches (Table 3) (Fig. 3).

Removal approaches of tracheal and bronchial foreign bodies
The study primarily utilized general anesthesia for removing tracheal and bronchial foreign bodies in 83.1% of instances, with sedation and local anesthesia less common at 11.9% and 5.1%, respectively.Rigid bronchoscopy was applied in 5.1% of cases, whereas flexible bronchoscopy was favored in 94.9%, reflecting a preference   4).

Discussion
With advancing age, tracheal and bronchial foreign body aspiration becomes increasingly prevalent 6,7 .It is often misdiagnosed or missed due to the lack of clear aspiration history, atypical symptoms, and characteristic imaging manifestations, leading to acute and chronic complications such as asphyxia, obstructive pneumonia, pulmonary atelectasis, and airway stenosis 5 .Following a comprehensive review of the literature on tracheal foreign bodies over the past five years, utilizing databases such as PubMed and Web of Science, we have synthesized the data regarding publications across different age demographics.Notably, case reports constitute nearly half of the publications within this timeframe.Among the remaining research articles, a predominant focus is observed on pediatric cases.The accompanying figure highlights the absence of studies involving older patient populations in the extant literature (Fig. 4 and Supplementary S1).We collected data from our hospital and identified 59 tracheal and bronchial foreign body cases occurring in elderly patients in the past five years.We analysed the data of these cases to understand the clinical characteristics of the trachea foreign body in the elderly.
In most of the older adults in our study, the time from the onset of symptoms to the hospital was between three days and one month.Our study found that older people in urban areas received treatment more promptly than those in rural areas.A study of foreign bodies in children had similar findings.The study found that children in urban areas were seen by doctors faster than those in rural areas 8 .
Our study found that the lower proportion of the elderly with definite aspiration history may be related to the reduced pharyngeal reflex in this population.A study of 234 patients compared the characteristics of tracheobronchial foreign bodies in different age groups and found that the proportion of the elderly with a definite history of aspiration was lower than that of the non-elderly group 8 .We anticipate an increase in predisposing diseases, including stroke, Parkinson's disease, and motor neuron disease, which will increase tracheal and bronchial foreign bodies.
Patients with respiratory problems may also have other medical disorders that may present with symptoms similar to those of tracheal and bronchial foreign bodies, such as conditions that affect neurological state or hinder deglutition 6 .In this study, the most common symptoms of patients with tracheal and bronchial foreign bodies were cough, phlegm, and dyspnea, but these symptoms were not specific.Some patients may have obstructive lesions such as abnormal density shadow, atelectasis, and pulmonary infiltration due to intrinsic foreign bodies, including sputum plug 9 .Therefore, diagnosing tracheal and bronchial foreign bodies depends significantly on    www.nature.com/scientificreports/history and clinical characteristics 7 .The manifestations under bronchoscopy are mainly purulent secretions 10 and granulation tissue hyperplasia.Bronchoscopic examination often reveals significant granulation tissue growth, indicating a prolonged duration of the foreign body presence, complicating removal.Our team usually takes comprehensive measures to remove refractory tracheal foreign bodies.High-frequency electrosurgical units can cauterize the granulation tissue around foreign bodies, loosening the foreign object.The cryoprobe can freeze together with the foreign body, forming a single unit, allowing multiple small foreign bodies to be removed at once.Balloons can dilate narrowed airways, facilitating the removal of foreign bodies.The types of foreign bodies in the trachea and bronchus were mainly food, and bone accounted for a large proportion, similar to previous literature reports 11 .This may be related to the lack of adequate care when the elderly are eating.At the same time, the types of foreign bodies have regional characteristics.People in coastal areas of Xiamen mostly eat seafood, so many seafood foreign bodies account for a relatively high proportion.In this study, dentures were also one of the components of foreign body inhalation.Adult patients older than 65 are more likely to experience foreign body aspiration 12,13 .Pills are also one of the components of inhaling foreign objects in the elderly.According to estimates, 7% of foreign body aspirations involve pills 14,15 .The right bronchus, particularly the mainstem or divisions of the right lower lobe bronchus, is the most often aspirated site in adults [16][17][18] .Interestingly, our study also found that some elderly foreign bodies were in the left bronchus.This may be related to the fact that these older people are unresponsive, fed by their families, and lie on their left side.
In 96.7% of our patients, bronchoscopy effectively eliminated tracheal and bronchial foreign bodies 4 .Foreign body forceps, biopsy forceps, and foreign body nets are commonly used as auxiliary tools for foreign body removal under bronchoscopy 19 .Most foreign bodies can be removed with a single tool such as an allis clamp, biopsy forceps, or alligator grasping forceps.For complex foreign bodies, it is necessary to combine with other  www.nature.com/scientificreports/bronchoscopic treatments 5 .Some patients even need rigid bronchoscopy for treatment because of the presence of foreign bodies for too long.
In conclusion, elderly patients with tracheobronchial foreign bodies often present with multiple comorbidities, a protracted disease course, and a notable absence of cough history, with nearly one-third remaining asymptomatic.The prolonged necessity for anti-infection measures further complicates management.Unlike pediatric cases, elderly patients are more likely to have food particles than metal objects as foreign bodies, posing detection challenges via CT imaging.Additionally, while the right trachea is a common site for foreign body lodgment, a significant proportion occurs in the less accessible left trachea.Given the advanced age, the presence of multiple underlying conditions, the atypical clinical and radiological presentations, and the heightened demands on endoscopic techniques and anesthesia, we emphasize the critical importance of vigilance towards tracheobronchial foreign bodies in the elderly, especially as China transitions into an aging society.This perspective underscores the need for tailored diagnostic and therapeutic approaches in this vulnerable population.

Figure 1 .
Figure 1.Relationship between place of residence and time elapsed between aspiration or symptoms and admission.Different lengths of time are represented in different colors (n = 59).(A) Urban area.(B) Rural area.

Figure 3 .
Figure 3. Sites of foreign bodies.Diagrams showing sites of foreign bodies in all cases (n = 59).Numbers in circles are case numbers.Numbers in the green background are percentages.

Figure 4 .
Figure 4. Summary of literature on tracheobronchial foreign bodies in the last five years.

Table 1 .
The characteristics of patients with tracheal and bronchial foreign bodies.Duration = Time elapsed between aspiration/symptoms and admission.

Table 2 .
Chest CT and bronchoscopic findings of tracheal and bronchial foreign bodies.

Table 3 .
Types and location of tracheal and bronchial foreign bodies.

Table 4 .
Removal approaches of tracheal and bronchial foreign bodies.